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The aqueous layer was then extracted with 6×200 ml of ethyl acetate before the aqueous was poured onto [2598 g;308M] of sodium hydrogen carbonate containing 300 ml of n-butanol.

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The reaction is monitored by analytical HPLC (46 x 50mm reversed phase Luna C18 column, lanoxin cmi 5 minute linear gradient 1-100% B buffer, A buffer is water with 01 % trifluoroacetic acid, B buffer is acetonitrile with 01 % trifluoroacetic acid)?

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